Department of Pathology & Laboratory Medicine

Greg Boivin, D.V.M.

Washington State University, D.V.M., 1989

The primary focus of Dr. Boivin’s laboratory is investigations into the pathology of genetically engineered mice. In collaboration with several investigators, the Division of Comparative Pathology, directed by Dr. Boivin, has examined the pathology of lesions in several systems, including cardiovascular, urogenital, endocrine, respiratory, and alimentary. Dr. Boivin also serves as the pathologist in collaborative studies involving examination of in vivo force modulation of healing in rabbit patellar tendon injuries.

Independent studies in Dr. Boivin’s laboratory include examining the cause of myositis in TGFb1-knockout mice. TGFb1-knockout mice develop an autoimmune disease involving many organs, and the skeletal muscle is a frequently targeted organ. The emphasis of Dr. Boivin’s work is to determine the inflammatory cell type involved in the lesions of the mutant mice.

Several other collaborative lines of investigation are currently funded in the Division of Comparative Pathology. These include investigations into developing genetically engineered mice as reporters of environmental genotoxicants, performing pathologic examination of mice with alterations of the a- and B-tropomyosin genes, and performing pathologic analysis of murine arthritis models to determine the optimal conditions for gene transfer to treat arthritis in humans.

Dr. Boivin is also the primary investigator on a Veterans Affairs Merit Review grant to examine the benefits of the use of Mesenchymal Stem Cells in the repair of tendon injuries in aging individuals.

Recent Publications

2.    Awad HA, Butler DL, Harris MT, Ibrahim RE, Wu YE, Young, RG, Kadiyala, S, Boivin GP. In vitro characterization of mesenchymal stem cell-seeded collagen scaffolds for tendon repair: Effects of initial seeding density on contraction kinetics.  J. Biomed. Mat. Res. 51:233-240, 2000.

3.    Thornton S, Boivin GP, Kim KN, Finkelman FD, Hirsch R. Heterogeneous effects of IL-2 on collagen-induced arthritis. J. Immun. 165:1557-1563, 2000.

4.    Zhang J, Lee H, Lou DW, Boivin GP, Xu M.  Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45-deficient thymocytes upon activation of apoptosis. Biochem. Biophys. Res. Comm. 274:225-229, 2000.

5.    Watanabe S, Imagawa T, Boivin GP, Gao G, Wilson JM, Hirsch R. Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Molecular Therapy. 2:147-152, 2000.

6.    Boivin GP, Schultheis PJ, Shull GE, Stemmermann GN. NHE-2 knockout mice develop a variant form of diffuse corporal gastritis. Comp. Med. 50:507-511, 2000.

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