Department of Pathology & Laboratory Medicine

Cecilia Fenoglio-Preiser, M.D.MacKenzie Professor and Director
Department of Pathology and Laboratory Medicine
 

Georgetown University College of Medicine, M.D., 1969

Cecilia Fenoglio-Preiser, M.D. has been involved for many years in investigations that define the molecular and phenotypic alterations associated with the development of malignancies. Experimental systems of interest encompass tumors of the gastrointestinal tract including the esophagus, stomach, colon, and anus. Each of these experimental systems are being investigated in terms of the pathobiology of the diseases as well as the potential use of individual tumor markers in diagnosis or prognosis of individual patients. Identification of new markers to define each stage in the evolution of cancer development allow one to detect patients at increased risk for cancer development. These markers also allow one to accurately assess the biology of a specific tumor in a specific patient. Experimental approaches involve analysis of oncogenes, tumor suppressor genes, genetic instability, and tumor clonality. Investigative techniques include the use of standard histological examination to molecular biologic analysis of patient outcomes.

Recent Publications

1. Shah RJ, Fenoglio-Preiser C, Bleau B, Giannella RA.  Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea.  Am J Gastro 96: 1091-1095, 2001.
2. Noffsinger A, Kretschmer S, Belli J, Fogt F, Fenoglio-Preiser C.  Microsatellite instability is uncommon in the intestinal mucosa of patients with Crohn’s disease. Dig Dis Sci 45:378-384, 2000
3. Compton C, Fenoglio-Preiser CM, Pettigrew N, Fielding LP American Joint Committee on Cancer      Prognostic Factors Consensus Conference: Colorectal Working Group. Cancer 88:1739-57, 2000
4. Grogan T, Fenoglio-Preiser C, Zeheb R, Bellamy W, Frutiger Y, Vela E, Stemmerman G, MacDonald J, Richter L, Gallegos A, Powis G. Thioredoxin, a putative oncogene product is overexpressed, in gastric carcinoma and associated with increased proliferation and increased survival. Human Pathol 31:475-481,2000
5. Shepherd T, Tolbert D, Benedetti J, Macdonald J, Stemmerman G, Wiest J, DeVoe, Miller MA, Wang J, Noffsinger A, Fenoglio-Preiser C.  Alterations in exon 4 of the p53 gene in gastric cancer. Gastroenterology, 118:1039-1044,2000
6. Lyda MH, Noffsinger A, Belli J, Fenoglio-Preiser CM. Microsatellite  instability and ras mutations in ulcerative colitis. Human Pathol,31:665-71,2000
7. Bejarrano PA, Aranda-Michelle J, Fenoglio-Preiser C. Histochemical and immunohistochemical characterization of foamy histiocytes (muciphages and xanthelasma) of rectum, Am J Surg Pathol 24:1009-1015,2000
8. Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Flejou J-F, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim Y, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Price AB, Rubio CA, Rugge M, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H. The Vienna classification of gastrointesinal epithelial neoplasia. Gut 47: 251-255,2000.

[ The Web at UC | UC Home ]

Questions? Contact Pathology e-mail.
Pathology & Laboratory Medicine; Room 1206 MSB, P.O. Box 670529.
Cincinnati, Ohio 45267-0529 ; (513) 558-4500