Department of Pathology & Laboratory Medicine
Norman A. Granholm, Ph.D.
office location: Medical Sciences Building, room 1411phone: 513-558-0182
e-mail address: granhona@email.uc.edu
Dr. Granholm graduated with his Ph.D. in Biology from the University
of Oregon. He then went on to complete his post graduate training at the
University of Texas, at the M.D. Anderson Hospital in Houston. Dr. Granholm
is interested in pathology, cell biology, immunology and nephrology.
Dr. Granholm is the leader for Core C: Immunology and Molecular
Biology of the Program Project Grant entitled Molecular Mechanisms of Cholesterol
Absortption (Dr. Hui, Principal Investigator). He collaborates with
the other members of the PPG and additionally, he pursues studies on the
mechanism of vascular injury induced by hyperhomocysteinemia. The
aims of these latter studies, in collaboration with Cheryl Emmons, M.D.,
(Internal Medicine, Nephrology Division, UC) are to determine whether the
vascular occlusive disease that occurs after endothelial injury is exacerbated
by hyperhomocysteinemia has altered intracellular calcium dynamics and
contractile properties.
Recent Publications:
- Ishigami M, Swertfeger DK, Hui M, Granholm NA, Hui, DY. Ishigami M, Swertfeger DK, Hui M, Granholm NA, Hui DY. Apolipoprotein E inhibition of vascular smooth muscle cell proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase. Arteriosclerosis Thromb Vasc Biol 2000; 20: 1020-6.
- McConihay JA, Honkomp AM, Granholm NA, Woollett LA. Maternal high density lipoproteins affect fetal mass and extra embryonic fetal tissue sterol metabolism in the mouse. J Lipid Res 2000; 41: 424-32.
- Granholm NA, Zhu B, Aronow BJ, Harmony JA, Hui DY. Apolipoprotein J/clusterin protects against neointima hyperplasia in the vascular response to arterial injury (abstract). Circulation 2000; 102 (Suppl):II-316.
- Richmond BL, Boileau AC, Zheng S, Huggins KW, Granholm NA, Tso P, Hui DY. Compensatory phospholipid digestion is required for normal cholesterol absorption in pancreatic phospholipase A2 gene targeted mice. Gastroenterology. 2000 (in press)
Lipid and Obesity Research
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