Education/Credentials:

  • Bachelor of Administration: Rice University
  • Doctorate: University of Texas at Austin

Professional Summary:

  • Dr. Jandacek was trained as a chemist and received a B. A. from Rice University and a Ph.D. from the University of Texas at Austin. 

    After two years in the Army at Walter Reed Army Institute of Research and the Armed Forces Institute of Pathology, he joined Procter and Gamble’s Miami Valley Laboratories in Cincinnati, where he worked until retiring in 2001. 

    At Procter & Gamble he became interested in the chemistry of lipids and its effects on their metabolism.  He studied the intestinal absorption of lipids and the nutritional, physical, and biological properties of olestra, a non-absorbable fat. 

    He is listed as inventor on 11 patents related to olestra and other lipids.  He was instrumental in establishing a formal collaboration in obesity research between Procter and Gamble and the University of Cincinnati. 

    He joined Dr. Tso’s laboratory as Adjunct Professor in 2001 and is the principal investigator of a clinical trial studying the nutritional interaction of lipids with toxic lipophilic xenobiotics.  This research is funded by a grant from the National Institute of Environmental Health Sciences. 

    He also directs the analysis of tissue fatty acids.  This work has led to the discovery of a facile method for the measurement of intestinal fat absorption.  This method was recently awarded a U.S. patent.  

    Dr. Jandacek is a member of the American Chemical Society, the American Oil Chemists’ Society, and the American Society for Nutrition.

Research Grants:

  • CHMC 508 / HEUBI05A0 Cystic Fibrosis Foundation. Fecal Behenic Acid: A New Marker for Fat Malabsorption, PI, 001062-001.
  • R21 ES019206 National Institute of Environmental Health Sciences. Intervention to Reduce Body Burden of PCBs in Residents of Anniston Alabama, PI, 007015-001.
  • R01 DK066596 National Inst of Diabetes and Digestive and Kidney Disease. Stress and Body Weight Regulation, Collaborator, Active.
  • U24 DK059630 National Inst of Diabetes and Digestive and Kidney Disease. Cincinnati Mouse Metabolic Phenotyping Center, Collaborator, Active.

Peer Reviewed Publications (in chronological order):

  • Kindel, T. L., Martins, P. J. F., Yoder, S. M., Jandacek, R. J., Seeley, R. J., & D (2011). Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents . Obesity (Silver Spring, Md.) , 19 (2) , 380-7.
  • Shen, L., Wang, D. Q., Tso, P., Jandacek, R. J., Woods, S. C., & Liu, M. (2011). (In Press). Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus. . Physiology & Behavior.
  • Jandacek, R. J., Rider, T., Keller, E. R., & Tso, P. (2010). The effect of olestra on the absorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; and perfluorooctanoic acid . Environment International , 36 (8) , 880-3.
  • Kohli, R., Kirby, M., Setchell, K. D. R., Jha, P., Klustaitis, K., Woollett, L. A., Pfluger, P. T., Balistreri, W. F., Tso, P., Jandacek, R. J., Woods, S. C., Heubi, J. E., Tschoep, M. H., & D (2010). Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (3) , G652-60.
  • Labonté, E. D., Pfluger, P. T., Cash, J. G., Kuhel, D. G., Roja, J. C., Magness, D. P., Jandacek, R. J., Tschöp, M. H., & Hui, D. Y. (2010). Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity . The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology , 24 (7) , 2516-24.
  • Ryan, K. K., Haller, A. M., Sorrell, J. E., Woods, S. C., Jandacek, R. J., & Seeley, R. J. (2010). Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice . Endocrinology , 151 (6) , 2603-12.
  • Arguin, H., Sánchez, M., Bray, G. A., Lovejoy, J. C., Peters, J. C., Jandacek, R. J., Chaput, J., & Tremblay, A. (2010). Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations: results from two pilot studies . The British Journal of Nutrition , 103 (10) , 1433-41.
  • Lo, C., King, A., Samuelson, L. C., Kindel, T. L., Rider, T., Jandacek, R. J., Raybould, H. E., Woods, S. C., & Tso, P. (2010). Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity . Gastroenterology , 138 (5) , 1997-2005.
  • Dorsey, J., Buckley, D., Summer, S., Jandacek, R. J., Rider, T., Tso, P., Narkewicz, M. R., & Heubi, J. E. (2010). Fat malabsorption in cystic fibrosis: comparison of quantitative fat assay and a novel assay using fecal lauric/behenic acid . Journal of Pediatric Gastroenterology and Nutrition , 50 (4) , 441-6.
  • Kohli, R., Kirby, M., Setchell, K. D. R., Jha, P., Klustaitis, K., Woollett, L. A., Pfluger, P. T., Balistreri, W. F., Tso, P., Jandacek, R. J., Woods, S. C., Heubi, J. E., Tschoep, M. H., D'Alessio, D. A., Shroyer, N. F., & Seeley, R. J. (2010). (In Press). Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (3) , G652-60.
  • Kirchner, H., Gutierrez, J. A., Solenberg, P. J., Pfluger, P. T., Czyzyk, T. A., Willency, J. A., Schürmann, A., Joost, H., Jandacek, R. J., Hale, J. E., Heiman, M. L., & Tschöp, M. H. (2009). GOAT links dietary lipids with the endocrine control of energy balance . Nature Medicine , 15 (7) , 741-5.
  • Jandacek, R. J., Rider, T., Yang, Q., Woollett, L. A., & Tso, P. (2009). Lymphatic and portal vein absorption of organochlorine compounds in rats . American Journal of Physiology. Gastrointestinal and Liver Physiology , 296 (2) , G226-34.
  • Brehm, B. J., Lattin, B. L., Summer, S. S., Boback, J. A., Gilchrist, G. M., Jandacek, R. J., & D (2009). One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes . Diabetes Care , 32 (2) , 215-20.
  • Battle, M. A., Bondow, B. J., Iverson, M. A., Adams, S. J., Jandacek, R. J., Tso, P., & Duncan, S. A. (2008). GATA4 is essential for jejunal function in mice . Gastroenterology , 135 (5) , 1676-1686.e1.
  • Labonté, E. D., Camarota, L. M., Rojas, J. C., Jandacek, R. J., Gilham, D. E., Davies, J. P., Ioannou, Y. A., Tso, P., Hui, D. Y., & Howles, P. N. (2008). (In Press). Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 295 (4) , G776-83.
  • Jones, K. S., Alimov, A. P., Rilo, H. L., Jandacek, R. J., Woollett, L. A., & Penberthy, W. T. (2008). A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development . Nutrition & Metabolism , 5 , 23.
  • Lo, C., Samuelson, L. C., Chambers, J. B., King, A., Heiman, J., Jandacek, R. J., Sakai, R. R., Benoit, S. C., Raybould, H. E., Woods, S. C., & Tso, P. (2008). (In Press). Characterization of mice lacking the gene for cholecystokinin. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 294 (3) , R803-10.
  • Bethune, M. T., Borda, J. T., Ribka, E., Liu, M., Phillippi-Falkenstein, K., Jandacek, R. J., Doxiadis, G. G. M., Gray, G. M., Khosla, C., & Sestak, K. (2008). (In Press). A non-human primate model for gluten sensitivity. . PloS One , 3 (2) , e1614.
  • Gilham, D., Labonté, E. D., Rojas, J. C., Jandacek, R. J., Howles, P. N., & Hui, D. Y. (2007). (In Press). Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout mice. . The Journal of Biological Chemistry , 282 (34) , 24642-9.
  • Duncan, E. A., Sorrell, J. E., Adamantidis, A., Rider, T., Jandacek, R. J., Seeley, R. J., Lakaye, B., & Woods, S. C. (2007). (In Press). Alcohol drinking in MCH receptor-1-deficient mice. . Alcoholism, Clinical and Experimental Research , 31 (8) , 1325-37.
  • Hennig, B., Ettinger, A. S., Jandacek, R. J., Koo, S., McClain, C., Seifried, H., Silverstone, A., Watkins, B., & Suk, W. A. (2007). (In Press). Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. . Environmental Health Perspectives , 115 (4) , 493-5.
  • Jandacek, R. J., & Tso, P. (2007). (In Press). Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention. . The Journal of Nutritional Biochemistry , 18 (3) , 163-7.
  • Duncan, E. A., Rider, T. R., Jandacek, R. J., Clegg, D. J., Benoit, S. C., Tso, P., & Woods, S. C. (2006). (In Press). The regulation of alcohol intake by melanin-concentrating hormone in rats. . Pharmacology, Biochemistry, and Behavior , 85 (4) , 728-35.
  • Nauli, A. M., Nassir, F., Zheng, S., Yang, Q., Lo, C., Vonlehmden, S. B., Lee, D., Jandacek, R. J., Abumrad, N. A., & Tso, P. (2006). (In Press). CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. . Gastroenterology , 131 (4) , 1197-207.
  • Jandacek, Ronald J (2005). (In Press). APD-356 (Arena). . Current Opinion in Investigational Drugs (London, England : 2000) , 6 (10) , 1051-6.
  • Redgrave, T. G., Wallace, P., Jandacek, R. J., & Tso, P. (2005). (In Press). Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. . The Journal of Nutritional Biochemistry , 16 (6) , 383-4.
  • Strader, A. D., Vahl, T. P., Jandacek, R. J., Woods, S. C., D'Alessio, D. A., & Seeley, R. J. (2005). (In Press). Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. . American Journal of Physiology. Endocrinology and Metabolism , 288 (2) , E447-53.
  • Jandacek, R. J., Anderson, N., Liu, M., Zheng, S., Yang, Q., & Tso, P. (2005). (In Press). Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 288 (2) , G292-9.
  • Jandacek, R. J., & Woods, S. C. (2004). (In Press). Pharmaceutical approaches to the treatment of obesity. . Drug Discovery Today , 9 (20) , 874-80.
  • Jandacek, R. J., Zheng, S., Yang, Q., & Tso, P. (2004). (In Press). Rapid clearance of hexachlorobenzene from chylomicrons. . Lipids , 39 (10) , 993-5.
  • Maiorano, J. N., Jandacek, R. J., Horace, E. M., & Davidson, W. S. (2004). (In Press). Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size. . Biochemistry , 43 (37) , 11717-26.
  • Jandacek, R. J., Heubi, J. E., & Tso, P. (2004). (In Press). A novel, noninvasive method for the measurement of intestinal fat absorption. . Gastroenterology , 127 (1) , 139-44.
  • Jandacek, R. J., & Tso, P. (2001). (In Press). Factors affecting the storage and excretion of toxic lipophilic xenobiotics. . Lipids , 36 (12) , 1289-305.
  • Hu, X., Jandacek, R. J., & White, W. S. (2000). (In Press). Intestinal absorption of beta-carotene ingested with a meal rich in sunflower oil or beef tallow: postprandial appearance in triacylglycerol-rich lipoproteins in women. . The American Journal of Clinical Nutrition , 71 (5) , 1170-80.
  • Cox, J. E., Tyler, W. J., Randich, A., Kelm, G. R., Bharaj, S. S., Jandacek, R. J., & Meller, S. T. (2000). (In Press). Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 278 (3) , R604-10.
  • Jandacek, R J (2000). (In Press). The canary in the cell: a sentinel role for beta-carotene. . The Journal of Nutrition , 130 (3) , 648-51.
  • Jandacek, R. J., Kester, J. J., Papa, A. J., Wehmeier, T. J., & Lin, P. Y. (1999). (In Press). Olestra formulation and the gastrointestinal tract. . Lipids , 34 (8) , 771-83.
  • Puppione, D. L., Kuehlthau, C. M., Jandacek, R. J., & Costa, D. P. (1996). (In Press). Chylomicron triacylglycerol fatty acids in suckling northern elephant seals (Mirounga angustirostris) resemble the composition and the distribution of fatty acids in milk fat. . Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology , 114 (1) , 53-7.
  • Wardlaw, G. M., Snook, J. T., Park, S., Patel, P. K., Pendley, F. C., Lee, M. S., & Jandacek, R. J. (1995). (In Press). Relative effects on serum lipids and apolipoproteins of a caprenin-rich diet compared with diets rich in palm oil/palm-kernel oil or butter. . The American Journal of Clinical Nutrition , 61 (3) , 535-42.
  • Puppione, D. L., Kuehlthau, C. M., Jandacek, R. J., & Costa, D. P. (1992). (In Press). Positional analyses of triacylglycerol fatty acids in the milk fat of the antarctic fur seal (Arctocephalus gazella). . Lipids , 27 (8) , 637-9.
  • Jandacek, R. J., & Holcombe, B. N. (1991). (In Press). The excretion and characterization of intravenously administered olestra. . Lipids , 26 (9) , 754-8.
  • Mattson, F. H., & Jandacek, R. J. (1991). (In Press). Distribution among tissues of intravenously administered sucrose octaoleate. . Lipids , 26 (9) , 750-3.
  • Jandacek, R. J., Ramirez, M. M., & Crouse, J. R. (1990). (In Press). Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man. . Metabolism: Clinical and Experimental , 39 (8) , 848-52.
  • Mutter, L. C., Blanke, R. V., Jandacek, R. J., & Guzelian, P. S. (1988). (In Press). Reduction in the body content of DDE in the Mongolian gerbil treated with sucrose polyester and caloric restriction. . Toxicology and Applied Pharmacology , 92 (3) , 428-35.
  • Jandacek, R. J., Whiteside, J. A., Holcombe, B. N., Volpenhein, R. A., & Taulbee, J. D. (1987). (In Press). The rapid hydrolysis and efficient absorption of triglycerides with octanoic acid in the 1 and 3 positions and long-chain fatty acid in the 2 position. . The American Journal of Clinical Nutrition , 45 (5) , 940-5.
  • Mattson, F. H., & Jandacek, R. J. (1985). (In Press). The effect of a non-absorbable fat on the turnover of plasma cholesterol in the rat. . Lipids , 20 (5) , 273-7.
  • Mellies, M. J., Vitale, C., Jandacek, R. J., Lamkin, G. E., & Glueck, C. J. (1985). (In Press). The substitution of sucrose polyester for dietary fat in obese, hypercholesterolemic outpatients. . The American Journal of Clinical Nutrition , 41 (1) , 1-12.
  • Jandacek, R J (1984). (In Press). Studies with sucrose polyester. . International Journal of Obesity , 8 Suppl 1 , 13-21.
  • Mellies, M. J., Jandacek, R. J., Taulbee, J. D., Tewksbury, M. B., Lamkin, G., Baehler, L., King, P., Boggs, D., Goldman, S., Gouge, A., Tsang, R., & Glueck, C. J. (1983). (In Press). A double-blind, placebo-controlled study of sucrose polyester in hypercholesterolemic outpatients. . The American Journal of Clinical Nutrition , 37 (3) , 339-46.
  • Jandacek, R J (1982). (In Press). The effect of nonabsorbable lipids on the intestinal absorption of lipophiles. . Drug Metabolism Reviews , 13 (4) , 695-714.
  • Glueck, C. J., Jandacek, R. J., Subbiah, M. T., Gallon, L., Yunker, R., Allen, C., Hogg, E., & Laskarzewski, P. M. (1980). (In Press). Effect of sucrose polyester on fecal bile acid excretion and composition in normal men. . The American Journal of Clinical Nutrition , 33 (10) , 2177-81.
  • Jandacek, R. J., Mattson, F. H., McNeely, S., Gallon, L., Yunker, R., & Glueck, C. J. (1980). (In Press). Effect of sucrose polyester on fecal steroid excretion by 24 normal men. . The American Journal of Clinical Nutrition , 33 (2) , 251-9.
  • Glueck, C. J., Mattson, F. H., & Jandacek, R. J. (1979). (In Press). The lowering of plasma cholesterol by sucrose polyester in subjects consuming diets with 800, 300, or less than 50 mg of cholesterol per day. . The American Journal of Clinical Nutrition , 32 (8) , 1636-44.
  • Jandacek, R. J., Webb, M. R., & Mattson, F. H. (1977). (In Press). Effect of an aqueous phase on the solubility of cholesterol in an oil phase. . Journal of Lipid Research , 18 (2) , 203-10.
  • Mattson, F. H., Jandacek, R. J., & Webb, M. R. (1976). (In Press). The effect of a nonabsorbable lipid, sucrose polyester, on the absorption of dietary cholesterol by the rat. . The Journal of Nutrition , 106 (6) , 747-52.
  • Jandacek, R. J., & Swartz, H. M. (1970). (In Press). The conformation of radioprotectant compounds. The crystal structures of 2-mercaptoethylamine hydrochloride and 3-mercaptopropylamine hydrochloride. . Radiation Research , 44 (2) , 523-30.