• Patrick Tso, PhD
  • Professor, Director, Mouse Metabolic Phenotype Center, Director, Physician Scientist Training Program
  •  
  • Metabolic Diseases Institute
  • Phone: (513) 558-2151
  • patrick.tso@uc.edu

Specialty/Interest:

  • One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine.

    The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology.

    We are currently studying how bile salts are involved in the absorption of lipids. In addition, we are also studying the factors regulating the synthesis and secretion of apolipoproteins by the small intestine.

    The apolipoproteins we are studying are: apo AI, apo AIV, apo B, and apo CIII.  

    Education/Credentials:

  • Doctorate: University of Western Australia

Research Grants:

  • 2 U24 DK059630-06 National Institute of Diabetes and Digestive and Kidney Diseases. Cincinnati Mouse Metabolic Phenotyping Center, PI, 000033-001.
  • R01 ES014464 National Institute of Environmental Health Sciences. Interaction of Nutrient and Organochlorine Absorption, PI, 002569-001.
  • 5-R01-DK-56910-05-A0-S0-E0 National Institute of Diabetes and Digestive and Kidney Diseases. Modulation of Intestinal Obesity Signals, PI, 003659-001.
  • 5-U24-DK-059630-01-A0-S0-E0 National Institute of Diabetes and Digestive and Kidney Diseases. Cincinnati Mouse Diabetes, PI, 003841-001.
  • Department of Agriculture. Toxic Lipophilic Xenobiotics: Tissue Distribution and Dietary Interactions, PI, 004089-001.
  • 5-R01-DK-53444-03-A0-S0-E0 National Institute of Diabetes and Digestive and Kidney Diseases. A Study of Hypothalamic Dysfunction in Zucker Obese Rats, PI, 004337-001.
  • 4-R01-DK-32288-14-A0-S0-E1 National Institute of Diabetes and Digestive and Kidney Diseases. Formation and Secretion of Intestinal Lipoproteins, PI, 004338-001.
  • R01 DK076928 National Institute of Diabetes and Digestive and Kidney Diseases. Functional and Molecular Study of Intestinal Cholesterol Transporters and Absorption, PI, 005055-001.
  • T32 GM063483 National Institute of General Medical Sciences. Medical Scientist Training Program, PI, 005326-001.
  • R56 HD034089 National Institute of Child Health and Human Development. Sterol Metabolism During Pregnancy and Development, Collaborator, 005802-001.
  • ZA02 Abbott Laboratories. Gastrointestinal Physiology, PI, 006108-001.
  • SRS 006117 Ajinomoto Co., Inc. (Japan). Determination of the Effect of MSG on the Absorption of Lipids, Secretion of Incretins and Satiety Peptides involved in Gastrointestinal Function, PI, 006117-001.
  • 3 R01 DK076928-03S1 National Institute of Diabetes and Digestive and Kidney Diseases. Functional & Molecular Study of Intestinal Cholesterol Transporters & Absorption, PI, 006405-001.
  • 3 T32 GM063483-08S2 National Institute of General Medical Sciences. Medical Scientist Training Program, PI, 006485-001.
  • 3 U24 DK059630-09S1 National Institute of Diabetes and Digestive and Kidney Diseases. Cincinnati Mouse Metabolic Phenotyping Center, PI, 006537-001.
  • SRS 006545 BioKier, Inc.. BioKier Study, PI, 006545-001.
  • HHMI 2010 Howard Hughes Medical Institute. Fellowship for Regan Memmott, PI, 007154-001.
  • R01 DK092138 National Institute of Diabetes and Digestive and Kidney Diseases. Gut Mucosal Mast Cells are Activated by Fat Absorption: Physiology and Mechanism, PI, 007413-001.
  • U24 DK076169 National Inst of Diabetes and Digestive and Kidney Disease. Coordinating & Bioinformatics Unit for the AMDCC/MMPC P&F Program, PI, Closed.
  • 1 R01 DK077170-01A2 National Inst of Diabetes and Digestive and Kidney Disease. Role of NPC1L1 in Regulating Energy Metabolism, Nutrient Utilization and Weight Gain, Collaborator, Active.
  • K01 DK087816 National Inst of Diabetes and Digestive and Kidney Disease. The Role of Visceral Fatty Acids in Relation to Insulin Resistance, Collaborator, Active.
  • U01 ES019480 National Institute of Environmental Health Sciences. Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk, Collaborator, Active.
  • F32DK091173 National Inst of Diabetes and Digestive and Kidney Disease. The Regulation of Hepatic Lipid Metabolism by Apolipoprotein AIV, Collaborator, Active.
  • R01 DK092779 National Inst of Diabetes and Digestive and Kidney Disease. Brain ApoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female Rats, Collaborator, Active.
  • U24 DK059630 National Inst of Diabetes and Digestive and Kidney Disease. Cincinnati Mouse Metabolic Phenotyping Center, PI, Active.
  • F30 HL097609 National Heart, Lung and Blood Institute. Role of RB/p16 Pathway in Pulmonary Progenitor Cell Regulation, Collaborator, Closed.

Peer Reviewed Publications (in chronological order):

  • Shen, L., Wang, D. Q., Tso, P., Jandacek, R. J., Woods, S. C., & Liu, M. (2011). Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus . Physiology & Behavior.
  • Clegg, D. J., Gotoh, K., Kemp, C., Wortman, M. D., Benoit, S. C., Brown, L. M., & D (2011). Consumption of a high-fat diet induces central insulin resistance independent of adiposity . Physiology & Behavior , 103 (1) , 10-6.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Cole-Strauss, A., & Lipton, J. W. (2011). Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: Relationship with stearoyl-CoA desaturase activity . Schizophrenia Research.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Cole-Strauss, A., & Lipton, J. W. (2011). Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression . Schizophrenia Research.
  • McNamara, R. K., Jandacek, R., Rider, T., & Tso, P. (2011). Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats . European Journal of Pharmacology , 652 (1-3) , 152-6.
  • Kohan, A. B., Qing, Y., Cyphert, H. A., Tso, P., & Salati, L. M. (2011). Chylomicron remnants and nonesterified fatty acids differ in their ability to inhibit genes involved in lipogenesis in rats . The Journal of Nutrition , 141 (2) , 171-6.
  • Kindel, T. L., Martins, P. J. F., Yoder, S. M., Jandacek, R. J., Seeley, R. J., & D (2011). Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents . Obesity (Silver Spring, Md.) , 19 (2) , 380-7.
  • Yang, L., Li, X., Ji, Y., Kohan, A. B., Wang, D. Q., Howles, P. N., Hui, D. Y., Lai, J., & Tso, P. (2010). Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (5) , G1003-11.
  • Kohan, A., Yoder, S., & Tso, P. (2010). Lymphatics in intestinal transport of nutrients and gastrointestinal hormones . Annals of the New York Academy of Sciences , 1207 Suppl 1 , E44-51.
  • Xiong, Y., Shen, L., Liu, K. J., Tso, P., Xiong, Y., Wang, G., Woods, S. C., & Liu, M. (2010). Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats . Diabetes , 59 (10) , 2505-12.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Dwivedi, Y., & Pandey, G. N. (2010). Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder . Journal of Affective Disorders , 126 (1-2) , 303-11.
  • McNamara, R. K., Able, J. A., Rider, T., Tso, P., & Jandacek, R. (2010). Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition . Progress in Neuro-psychopharmacology & Biological Psychiatry , 34 (7) , 1317-21.
  • Kohli, R., Kirby, M., Setchell, K. D. R., Jha, P., Klustaitis, K., Woollett, L. A., Pfluger, P. T., Balistreri, W. F., Tso, P., Jandacek, R. J., Woods, S. C., Heubi, J. E., Tschoep, M. H., & D (2010). Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (3) , G652-60.
  • Yoder, S. M., Yang, Q., Kindel, T. L., & Tso, P. (2010). Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (2) , G476-85.
  • Ellacott, K. L. J., Morton, G. J., Woods, S. C., Tso, P., & Schwartz, M. W. (2010). Assessment of feeding behavior in laboratory mice . Cell Metabolism , 12 (1) , 10-7.
  • Shen, L., Wang, D. Q., Lo, C., Tso, P., Davidson, W. S., Woods, S. C., & Liu, M. (2010). Estradiol increases the anorectic effect of central apolipoprotein A-IV . Endocrinology , 151 (7) , 3163-8.
  • Kindel, T., Lee, D. M., & Tso, P. (2010). (In Press). The mechanism of the formation and secretion of chylomicrons. . Atherosclerosis. Supplements , 11 (1) , 11-6.
  • Kindel, T. L., Yoder, S. M., D'Alessio, D. A., & Tso, P. (2010). (In Press). The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats. . Obesity Surgery , 20 (6) , 768-75.
  • Lo, C., King, A., Samuelson, L. C., Kindel, T. L., Rider, T., Jandacek, R. J., Raybould, H. E., Woods, S. C., & Tso, P. (2010). (In Press). Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. . Gastroenterology , 138 (5) , 1997-2005.
  • McNamara, R. K., Able, J., Jandacek, R., Rider, T., Tso, P., Eliassen, J. C., Alfieri, D., Weber, W., Jarvis, K., DelBello, M. P., Strakowski, S. M., & Adler, C. M. (2010). (In Press). Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. . The American Journal of Clinical Nutrition , 91 (4) , 1060-7.
  • Dorsey, J., Buckley, D., Summer, S., Jandacek, R. J., Rider, T., Tso, P., Narkewicz, M. R., & Heubi, J. E. (2010). (In Press). Fat malabsorption in cystic fibrosis: comparison of quantitative fat assay and a novel assay using fecal lauric/behenic acid. . Journal of Pediatric Gastroenterology and Nutrition , 50 (4) , 441-6.
  • Yoder, S. M., Kindel, T. L., & Tso, P. (2010). (In Press). Using the lymph fistula rat model to study incretin secretion. . Vitamins and Hormones , 84 , 221-49.
  • Kaplan, K., Dwivedi, P., Davidson, S., Yang, Q., Tso, P., Siems, W., & Hill, H. H. (2009). (In Press). Monitoring dynamic changes in lymph metabolome of fasting and fed rats by electrospray ionization-ion mobility mass spectrometry (ESI-IMMS). . Analytical Chemistry , 81 (19) , 7944-53.
  • Kindel, T. L., Yoder, S. M., Seeley, R. J., D'Alessio, D. A., & Tso, P. (2009). (In Press). Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. . Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract , 13 (10) , 1762-72.
  • Shen, L., Tso, P., Wang, D. Q., Woods, S. C., Davidson, W. S., Sakai, R., & Liu, M. (2009). (In Press). Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. . Physiology & Behavior , 98 (1-2) , 223-8.
  • Yoder, S. M., Yang, Q., Kindel, T. L., & Tso, P. (2009). (In Press). Stimulation of incretin secretion by dietary lipid: is it dose dependent? . American Journal of Physiology. Gastrointestinal and Liver Physiology , 297 (2) , G299-305.
  • Burke, K. T., Horn, P. S., Tso, P., Heubi, J. E., & Woollett, L. A. (2009). (In Press). Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 297 (1) , G144-51.
  • McNamara, R. K., Able, J., Jandacek, R., Rider, T., & Tso, P. (2009). (In Press). Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. . Psychoneuroendocrinology , 34 (4) , 532-9.
  • Liu, Y., Jandacek, R., Rider, T., Tso, P., & McNamara, R. K. (2009). (In Press). Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. . Schizophrenia Research , 109 (1-3) , 113-20.
  • McNamara, R. K., Able, J., Jandacek, R., Rider, T., Tso, P., & Lindquist, D. M. (2009). (In Press). Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. . Journal of Lipid Research , 50 (3) , 405-11.
  • McNamara, R. K., Able, J., Liu, Y., Jandacek, R., Rider, T., Tso, P., & Lipton, J. W. (2009). (In Press). Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. . Journal of Psychiatric Research , 43 (6) , 656-63.
  • Kindel, T. L., Yang, Q., Yoder, S. M., & Tso, P. (2009). (In Press). Nutrient-driven incretin secretion into intestinal lymph is different between diabetic Goto-Kakizaki rats and Wistar rats. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 296 (2) , G168-74.
  • Jandacek, R. J., Rider, T., Yang, Q., Woollett, L. A., & Tso, P. (2009). (In Press). Lymphatic and portal vein absorption of organochlorine compounds in rats. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 296 (2) , G226-34.
  • McNamara, R. K., Able, J. A., Jandacek, R., Rider, T., & Tso, P. (2009). (In Press). Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. . Schizophrenia Research , 107 (2-3) , 150-7.
  • Lo, C., Xu, M., Yang, Q., Zheng, S., Carey, K. M., Tubb, M. R., Davidson, W. S., Liu, M., Woods, S. C., & Tso, P. (2009). (In Press). Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 296 (1) , R43-50.
  • McNamara, R. K., Able, J., Jandacek, R., Rider, T., & Tso, P. (2009). (In Press). Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition. . Lipids , 44 (1) , 1-8.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Dwivedi, Y., Roberts, R. C., Conley, R. R., & Pandey, G. N. (2009). (In Press). Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims. . Prostaglandins, Leukotrienes, and Essential Fatty Acids , 80 (1) , 19-26.
  • Battle, M. A., Bondow, B. J., Iverson, M. A., Adams, S. J., Jandacek, R. J., Tso, P., & Duncan, S. A. (2008). (In Press). GATA4 is essential for jejunal function in mice. . Gastroenterology , 135 (5) , 1676-1686.e1.
  • Labonté, E. D., Camarota, L. M., Rojas, J. C., Jandacek, R. J., Gilham, D. E., Davies, J. P., Ioannou, Y. A., Tso, P., Hui, D. Y., & Howles, P. N. (2008). (In Press). Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 295 (4) , G776-83.
  • McNamara, R. K., Sullivan, J., Richtand, N. M., Jandacek, R., Rider, T., Tso, P., Campbell, N., & Lipton, J. (2008). (In Press). Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. . Synapse (New York, N.Y.) , 62 (10) , 725-35.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Stanford, K. E., Hahn, C., & Richtand, N. M. (2008). (In Press). Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. . Psychiatry Research , 160 (3) , 285-99.
  • Shen, L., Pearson, K. J., Xiong, Y., Lo, C., Tso, P., Woods, S. C., Davidson, W. S., & Liu, M. (2008). (In Press). Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. . Physiology & Behavior , 95 (1-2) , 161-7.
  • Shen, L., Tso, P., Woods, S. C., Clegg, D. J., Barber, K. L., Carey, K., & Liu, M. (2008). (In Press). Brain apolipoprotein E: an important regulator of food intake in rats. . Diabetes , 57 (8) , 2092-8.
  • Tubb, M. R., Silva, R. A. G. D., Fang, J., Tso, P., & Davidson, W. S. (2008). (In Press). A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry. . The Journal of Biological Chemistry , 283 (25) , 17314-23.
  • Lu, W. J., Yang, Q., Sun, W., Woods, S. C., D'Alessio, D., & Tso, P. (2008). (In Press). Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 294 (5) , G1130-8.
  • Lo, C., Samuelson, L. C., Chambers, J. B., King, A., Heiman, J., Jandacek, R. J., Sakai, R. R., Benoit, S. C., Raybould, H. E., Woods, S. C., & Tso, P. (2008). (In Press). Characterization of mice lacking the gene for cholecystokinin. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 294 (3) , R803-10.
  • D'Alessio, D., Lu, W., Sun, W., Zheng, S., Yang, Q., Seeley, R., Woods, S. C., & Tso, P. (2007). (In Press). Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 293 (6) , R2163-9.
  • Lo, C. M., Zhang, D. M., Pearson, K., Ma, L., Sun, W., Sakai, R. R., Davidson, W. S., Liu, M., Raybould, H. E., Woods, S. C., & Tso, P. (2007). (In Press). Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 293 (4) , R1490-4.
  • Tubb, M. R., Silva, R. A. G. D., Pearson, K. J., Tso, P., Liu, M., & Davidson, W. S. (2007). (In Press). Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. . The Journal of Biological Chemistry , 282 (39) , 28385-94.
  • McNamara, R. K., Hahn, C., Jandacek, R., Rider, T., Tso, P., Stanford, K. E., & Richtand, N. M. (2007). (In Press). Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. . Biological Psychiatry , 62 (1) , 17-24.
  • Shen, L., Tso, P., Woods, S. C., Sakai, R. R., Davidson, W. S., & Liu, M. (2007). (In Press). Hypothalamic apolipoprotein A-IV is regulated by leptin. . Endocrinology , 148 (6) , 2681-9.
  • Jandacek, R. J., & Tso, P. (2007). (In Press). Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention. . The Journal of Nutritional Biochemistry , 18 (3) , 163-7.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Hahn, C., Richtand, N. M., & Stanford, K. E. (2007). (In Press). Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. . Schizophrenia Research , 91 (1-3) , 37-50.
  • Lo, C., Ma, L., Zhang, D. M., Lee, R., Qin, A., Liu, M., Woods, S. C., Sakai, R. R., Raybould, H. E., & Tso, P. (2007). (In Press). Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 292 (1) , R268-73.
  • Duncan, E. A., Rider, T. R., Jandacek, R. J., Clegg, D. J., Benoit, S. C., Tso, P., & Woods, S. C. (2006). (In Press). The regulation of alcohol intake by melanin-concentrating hormone in rats. . Pharmacology, Biochemistry, and Behavior , 85 (4) , 728-35.
  • Nauli, A. M., Nassir, F., Zheng, S., Yang, Q., Lo, C., Vonlehmden, S. B., Lee, D., Jandacek, R. J., Abumrad, N. A., & Tso, P. (2006). (In Press). CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. . Gastroenterology , 131 (4) , 1197-207.
  • Trevaskis, N. L., Tso, P., Rider, T., Charman, W. N., Porter, C. J. H., & Jandacek, R. (2006). (In Press). Tissue uptake of DDT is independent of chylomicron metabolism. . Archives of Toxicology , 80 (4) , 196-200.
  • Gotoh, K., Liu, M., Benoit, S. C., Clegg, D. J., Davidson, W. S., D'Alessio, D., Seeley, R. J., Tso, P., & Woods, S. C. (2006). (In Press). Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 290 (1) , R202-7.
  • Pearson, K., Tubb, M. R., Tanaka, M., Zhang, X. Q., Tso, P., Weinberg, R. B., & Davidson, W. S. (2005). (In Press). Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. . The Journal of Biological Chemistry , 280 (46) , 38576-82.
  • Proulx, K., Cota, D., Castañeda, T. R., Tschöp, M. H., D'Alessio, D. A., Tso, P., Woods, S. C., & Seeley, R. J. (2005). (In Press). Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 289 (3) , R729-37.
  • Redgrave, T. G., Wallace, P., Jandacek, R. J., & Tso, P. (2005). (In Press). Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. . The Journal of Nutritional Biochemistry , 16 (6) , 383-4.
  • Pearson, K., Liu, M., Shen, L., Tso, P., & Davidson, W. S. (2005). (In Press). Bacterial expression and characterization of rat apolipoprotein E. . Protein Expression and Purification , 41 (2) , 447-53.
  • Qin, X., Shen, H., Liu, M., Yang, Q., Zheng, S., Sabo, M., D'Alessio, D. A., & Tso, P. (2005). (In Press). GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 288 (5) , G943-9.
  • Jandacek, R. J., Anderson, N., Liu, M., Zheng, S., Yang, Q., & Tso, P. (2005). (In Press). Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 288 (2) , G292-9.
  • Tso, P., & Liu, M. (2004). (In Press). Apolipoprotein A-IV, food intake, and obesity. . Physiology & Behavior , 83 (4) , 631-43.
  • Woods, S. C., D'Alessio, D. A., Tso, P., Rushing, P. A., Clegg, D. J., Benoit, S. C., Gotoh, K., Liu, M., & Seeley, R. J. (2004). (In Press). Consumption of a high-fat diet alters the homeostatic regulation of energy balance. . Physiology & Behavior , 83 (4) , 573-8.
  • Jandacek, R. J., Zheng, S., Yang, Q., & Tso, P. (2004). (In Press). Rapid clearance of hexachlorobenzene from chylomicrons. . Lipids , 39 (10) , 993-5.
  • Pearson, K., Saito, H., Woods, S. C., Lund-Katz, S., Tso, P., Phillips, M. C., & Davidson, W. S. (2004). (In Press). Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications. . Biochemistry , 43 (33) , 10719-29.
  • Liu, M., Shen, L., Liu, Y., Woods, S. C., Seeley, R. J., D'Alessio, D., & Tso, P. (2004). (In Press). Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus. . American Journal of Physiology. Endocrinology and Metabolism , 287 (2) , E366-70.
  • Liu, M., Shen, L., Liu, Y., Tajima, D., Sakai, R., Woods, S. C., & Tso, P. (2004). (In Press). Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. . Endocrinology , 145 (7) , 3232-8.
  • Jandacek, R. J., Heubi, J. E., & Tso, P. (2004). (In Press). A novel, noninvasive method for the measurement of intestinal fat absorption. . Gastroenterology , 127 (1) , 139-44.
  • Vowinkel, T., Mori, M., Krieglstein, C. F., Russell, J., Saijo, F., Bharwani, S., Turnage, R. H., Davidson, W. S., Tso, P., Granger, D. N., & Kalogeris, T. J. (2004). (In Press). Apolipoprotein A-IV inhibits experimental colitis. . The Journal of Clinical Investigation , 114 (2) , 260-9.
  • Tso, P., Sun, W., & Liu, M. (2004). (In Press). Gastrointestinal satiety signals IV. Apolipoprotein A-IV. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 286 (6) , G885-90.
  • Tso, P., & Liu, M. (2004). (In Press). Ingested fat and satiety. . Physiology & Behavior , 81 (2) , 275-87.
  • Woollett, L. A., Buckley, D. D., Yao, L., Jones, P. J. H., Granholm, N. A., Tolley, E. A., Tso, P., & Heubi, J. E. (2004). (In Press). Cholic acid supplementation enhances cholesterol absorption in humans. . Gastroenterology , 126 (3) , 724-31.
  • Liu, M., Doi, T., & Tso, P. (2003). (In Press). Regulation of intestinal and hypothalamic apolipoprotein A-IV. . Experimental Biology and Medicine (Maywood, N.J.) , 228 (10) , 1181-9.
  • Clegg, D. J., Benoit, S. C., Air, E. L., Jackman, A., Tso, P., D'Alessio, D., Woods, S. C., & Seeley, R. J. (2003). (In Press). Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. . Endocrinology , 144 (7) , 2941-6.
  • Liu, M., Shen, L., Doi, T., Woods, S. C., Seeley, R. J., & Tso, P. (2003). (In Press). Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. . Brain Research , 971 (2) , 232-8.
  • Nauli, A. M., Zheng, S., Yang, Q., Li, R., Jandacek, R., & Tso, P. (2003). (In Press). Intestinal alkaline phosphatase release is not associated with chylomicron formation. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 284 (4) , G583-7.
  • Woods, S. C., Seeley, R. J., Rushing, P. A., D'Alessio, D., & Tso, P. (2003). (In Press). A controlled high-fat diet induces an obese syndrome in rats. . The Journal of Nutrition , 133 (4) , 1081-7.
  • Liu, M., Maiorano, N., Shen, L., Pearson, K., Tajima, D., Zhang, D. M., Woods, S. C., Seeley, R. J., Davidson, W. S., & Tso, P. (2003). (In Press). Expression of biologically active rat apolipoprotein AIV in Escherichia coli. . Physiology & Behavior , 78 (1) , 149-55.
  • Yao, L., Heubi, J. E., Buckley, D. D., Fierra, H., Setchell, K. D. R., Granholm, N. A., Tso, P., Hui, D. Y., & Woollett, L. A. (2002). (In Press). Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. . Journal of Lipid Research , 43 (4) , 654-60.
  • Kirby, R. J., Zheng, S., Tso, P., Howles, P. N., & Hui, D. Y. (2002). (In Press). Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. . The Journal of Biological Chemistry , 277 (6) , 4104-9.
  • Tso, P., Ding, K., DeMichele, S., & Huang, Y. (2002). (In Press). Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. . The Journal of Nutrition , 132 (2) , 218-21.
  • McNamara, R. K., Jandacek, R., Rider, T., Tso, P., Cole-Strauss, A., & Lipton, J. W. Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover . Prostaglandins, Leukotrienes, and Essential Fatty Acids , 83 (4-6) , 185-91.
  • McNamara, R. K., Liu, Y., Jandacek, R., Rider, T., & Tso, P. (In Press). The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. . Prostaglandins, Leukotrienes, and Essential Fatty Acids , 78 (4-5) , 293-304.